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In addition, Li et al. have discovered that the upregulation of PI3K/AKT pathway promotes the expressions of placental development variable (PlGF) and C-X-C Motif Chemokine Ligand one (CXCL1) in lung most cancers stem cells, which more encourage angiogenesis [59]. CCPlenty of paracrine components secreted by MSCs are ligands for receptors that acti

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